The image of Jesus Christ has been reported on everything from a slice of toast to a laundry sock - but it's hard to beat the extraordinary creation of a 'smiley face' on a cancer tumour.
Sydney researchers have been astonished as they have watched the face develop on a laboratory-produced cancer protein which develops into tumours.
The scientists at the Westmead Millennium Institute for Medical Research created the cancer protein 12 years ago to learn how it would develop into a tumour in the human body.
But the experiment produced more than they had bargained for when the smiley face began to develop over the years.
'We have never seen any like this before,' said Associate Professor Beric Henderson, leading the research.